Digital Twins in Medicine

A Digital Twin is a virtual representation of a patient that can be used to predict and analyze various medical scenarios and treatments.

The origin of the Digital Twin concept is in the engineering disciplines, but recently gained a lot of attention in medical areas as tool to enable personalized healthcare. The Digital Twin incorporates high-level Machine Learning and integrates individual-level data, such as proteome and clinical characteristics, with other factors like clinical trials and population studies to create a multiscale and multimodal data set for model training.

Interpretable Machine Learning and Evidence-based decision-making

For medical applications, black-box Machine Learning must be avoided. For the doctor to make informed decisions, it is important to enable

  1. An intuitively interpretable decision support and
  2. Inclusion of current evidence-based knowledge and clinical guidelines

Our unique Digital Twin platform enables a versatile and agnostic decision support system and intrinsic plus state-of-the-art interpretation techniques.

Use case: Urology

We work closely with medical doctors from the University Hospital and are focusing on the diagnosis of Prostate Cancer. The Urology department of the University Hospital offers a unique database of prostate cancer patients. Therefore, we are able to develop state-of-the-art machine learning pipelines and have a direct impact on the clinical patient care.

Use case: Global Health

Together with the Heidelberg Institute for Global Health, we investigate the possibility to use Digital Twins as risk prediction tool for population diseases worldwide. We aim to predict the apperance of diabetes and hyptertonia as well as directly offering treatment options.

  • Anna-Katharina Nitschke starts her PhD in the Digital Twins team

    Anna stays with the Digital Twin group after successfully finishing her Master Thesis about an Architecture of Digital Twins of Patients in Urology and will continue her research on Digital Twins in Medicine for applications in Global Health together with partners from the Heidelberg Institute of Global Health and STRUCTURES. We wish good luck!

  • Digital Twin project starts

    A new project starts in the group. The Digital Twin group consists of two members, Anna Nitscke, who wants to start her master thesis in this project. And Carlos Brandl, who starts his PhD after being a Master student at the Rydberg team. Together with Prof. Ommer from the IWR the team tries to find new ways of creating digital twins for medicine. The project is part of the collaborative CLINIC5.1 project, lead by the University Hospital and funded by the BMWK.

Recent publications


Wadenpfuhl K

Emergence of synchronisation in a driven-dissipative hot Rydberg vapour Masters Thesis


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Welz K, Gerken M, Zhu B, Lippi E, Rautenberg M, Chomaz L, Weidemüller M

Anomalous loss behavior in a single-component Fermi gas close to a p-wave Feshbach resonance Journal Article

In: Phys. Rev. A, vol. 107, iss. 5, pp. 053310, 2023.

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Tran B

From Efimov Physics to Polarons in an Ultracold Mixture of Li and Cs Atoms PhD Thesis


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Hassan S Z

Dynamics of anions and ultracold atoms in a hybrid atom-ion trap PhD Thesis


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Gerken M

Exploring p-wave Feshbach Resonances in Ultracold Lithium and Lithium-Cesium Mixtures PhD Thesis


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Alves R F

Realization of a Heisenberg XXZ spin system using Rydberg atoms PhD Thesis


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Tan C, Lin X, Zhou Y, Jiang Y H, Weidemüller M, Zhu B

Dynamics of position disordered Ising spins with a soft-core potential Journal Article

In: Phys. Rev. B, vol. 105, pp. 104204, 2022.

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Hu F, Tan C, Jiang Y, Weidemüller M, Zhu B

Observation of photon recoil effects in single-beam absorption spectroscopy with an ultracold strontium gas Journal Article

In: Chin. Phys. B, vol. 31, pp. 016702, 2022.

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Scholl P, Williams H J, Bornet G, Wallner F, Barredo D, Lahaye T, Henriet L, Signoles A, Hainaut C, Franz T, Geier S, Tebben A, Zürn G, Salzinger A, Weidemüller M, Browaeys A

Microwave-engineering of programmable XXZ Hamiltonians in arrays of Rydberg atoms Journal Article

In: Phys. Rev. X Quantum, vol. 3, pp. 020303, 2022.

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Schultzen P, Franz T, Hainaut C, Geier S, Salzinger A, Tebben A, Zürn G, Gärttner M, Weidemüller M

Semiclassical simulations predict glassy dynamics for disordered Heisenberg models Journal Article

In: Phys. Rev. B, 2022.

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Schultzen P, Franz T, Geier S, Salzinger A, Tebben A, Hainaut C, Zürn G, Weidemüller M, Gärttner M

Glassy quantum dynamics of disordered Ising spins Journal Article

In: Phys. Rev. B, vol. 105, pp. L020201, 2022.

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Hassan S Z, Tauch J, Kas M, Nötzold M, Carrera H L, Endres E S, Wester R, Weidemüller M

Associative detachment in anion-atom reactions involving a dipole-bound electron Journal Article

In: Nat. Comm., vol. 13, pp. 818, 2022.

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Hassan S Z, Tauch J, Kas M, Nötzold M, Wester R, Weidemüller M

Quantum state-dependent anion-neutral detachment processes Journal Article

In: J. Chem. Phys., vol. 156, pp. 094304, 2022.

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Bharti V, Sugawa S, Mizoguchi M, Kunimi M, Zhang Y, de Léséleuc S, Tomita T, Franz T, Weidemüller M, Ohmori K

Ultrafast Many-Body Dynamics in an Ultracold Rydberg-Excited Atomic Mott Insulator Working paper

arXiv e-prints: 2201.09590, 2022.

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Tebben A

Rydberg Electromagnetically Induced Transparency - A vanishing linear response, resonances, and a stationary Rydberg polariton PhD Thesis


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Tauch J

New approaches for cooling molecular anions to the Kelvin range PhD Thesis


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Wintermantel T M

Complex systems dynamics in laser excited ensembles of Rydberg atoms PhD Thesis


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Geier S, Thaicharoen N, Hainaut C, Franz T, Salzinger A, Tebben A, Grimshandl D, Zürn G, Weidemüller M

Floquet Hamiltonian Engineering of an Isolated Many-Body Spin System Journal Article

In: Science, vol. 374, pp. 1149, 2021.

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Stutterheim C, Weidemüller M

Was die Welt zusammenhält: Babel und Bubbles Online

2021, visited: 01.01.2021.

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Tran B, Rautenberg M, Gerken M, Lippi E, Zhu B, Ulmanis J, Drescher M, Salmhofer M, Enss T, Weidemüller M

Fermions meet two bosons -- the heteronuclear Efimov effect revisited Journal Article

In: Braz. J. Phys., vol. 51, pp. 316, 2021.

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Signoles A, Franz T, Alves R F, Gärttner M, Whitlock S, Zürn G, Weidemüller M

Observation of glassy dynamics in a disordered quantum spin system Journal Article

In: Phys. Rev. X, vol. 11, pp. 011011, 2021.

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Tebben A, Hainaut C, Salzinger A, Geier S, Franz T, Pohl T, Gärttner M, Zürn G, Weidemüller M

Nonlinear absorption in interacting Rydberg electromagnetically-induced-transparency spectra on two-photon resonance Journal Article

In: Phys. Rev. A, vol. 103, pp. 063710, 2021.

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Qiao C, Tan C, Siegl J, Hu F, Niu Z, Jiang Y, Weidemüller M, Zhu B

Rydberg blockade in an ultracold strontium gas revealed by two-photon excitation dynamics Journal Article

In: Phys. Rev. A, vol. 103, pp. 063313, 2021.

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